Oxidative stress in the pathogenesis of Alzheimer's disease: Improvement of memory-deteriorating disease by administration of plant enzyme

Plant enzymes are natural substances with almost no side effects and reported on spatial learning histopathological alterations of the hippocampus in senescence-accelerated mice. In mice (SAMP8), this vivo study examined a plant enzyme brain hippocampus, memory cognition. Morris water maze, comparison between control group SAMR1 sham SAMP8 (SAMP8 without administration) showed significant reduction arrival time, probe test, it was divided into 4 divisions. Moreover, there increase dwell time number crossings virtual platform area. The enzyme-treated tended to have shorter than group, but not significantly different. Serum peroxy radicals were suppressed compared group. inhibited radical control. With treatment, lipid peroxidation level lowered tissue (p < 0.05. Serotonin (5-HT) levels higher -treated that There difference peroxide concentration administration contrast, serotonin different high neuron density (CA1 region) animals indicates possible improvement memory.